Immune Profiling is the detailed study and characterization of both the innate and adaptive immune responses to provide crucial insights into disease mechanisms and aiding in the development of novel therapeutic strategies. The innate immune system serves as the body’s first line of defense, employing various cells (macrophages, neutrophils, and natural killer cells) and mechanisms to recognize and swiftly respond to pathogens. On the other hand, the adaptive immune system is highly specialized and tailored to specific pathogens. It consists of T-cells and B-cells that undergo a process of activation, proliferation, and differentiation to produce targeted responses through the generation of antibodies (from B-cells) and the coordination of cellular immune responses.
T-cells also act to coordinate cytokines and immune cells to fight viruses and other foreign intruders, protecting the body from these threats and fighting off infection. A proportion of these T-cells remain in the body for many years after recovery, as memory cells, to protect the body if it was to come in contact with the same, or similar viruses in the future. Detecting the cytokines associated with conditions involved with T-Cell exhaustion and chronic fatigue such as Long COVID can be useful in determining cellular responses.
FluoroSpot T-Cell Technology is an established technology for the detection and quantification of multiple cytokine-secreting cells, providing higher resolution of cellular immune responses and easier adoption for laboratories. It is distinct from ELISA and flow cytometry techniques which are limited to either not knowing the cellular origin of the cytokine release or are limited in its ability to elucidate the complex immune dynamics.
Our ViraxImmune™ FluoroSpot IVD platform is built around developing peptide pools designed to activate memory T-cells and measuring the cytokine release profile specific to the infection. The platform is not restricted to a single disease or condition allowing the platform to address a wide range of research and diagnostic needs within indications associated with chronic inflammation and T-cell exhaustion including post-viral syndromes.